What is Hereditary Angioedema?
Hereditary Angioedema (HAE) is a rare but serious disease passed down through families. HAE is caused by the lack of or improper function of a natural protein called C1 esterase inhibitor, which helps maintain the normal flow of fluids through small blood vessels known as capillaries. HAE leads to fluid accumulation outside of blood vessels, which can occur anywhere in the body but typically manifests as swelling in the abdomen, hands, feet, face, and/or the airway.
Signs and Symptoms
The nature of HAE varies greatly and changes with age. Untreated attacks can last from 2 to 5 days and occur as frequently as once a week or only a few times per year.
Typical symptoms of HAE are: